Arylcyclobutylalkylamines and anti-depression composition and me

Details Arylcyclobutylalkylamines and anti-depression composition and me Arylcyclobutylalkylamines and anti-depression composition and me

1982-04-05

1984-04-17

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424263, 424267, 424274, 424330, 544403, 546346, 546348, 548578, 564428, 564442, 564305, A61K 31135, C07C 8728

Patent

active

044434499

ABSTRACT:
Compounds of formula I ##STR1## in which R.sub.1 is H or C.sub.1-3 alkyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, or C.sub.1-3 alkyl (with the proviso that R.sub.5 and R.sub.6 cannot both be H or methyl) or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring and R.sub.7 and/or R.sub.8 are H or C.sub.1-3 alkyl show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.

REFERENCES:
Arya et al., Ind. J. of Chem., vol. 14B, pp. 766-769, (1976).
Mndzhoyan et al., Armyanskii Khimichesdii Zhurnal, vol. 29, No. 2, pp. 194-199, (1976).

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