Arylcarbonylaminoalkyl-dihydro-oxo-pyridines, their production a

Details Arylcarbonylaminoalkyl-dihydro-oxo-pyridines, their production a Arylcarbonylaminoalkyl-dihydro-oxo-pyridines, their production a

1993-02-18

1994-11-01

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546261, 546291, 546298, 544360, C07D21364, A61K 3144

Patent

active

053608089

ABSTRACT:
Arylcarbonylaminoalkyl-dihydro-oxo-pyridines of Formula I ##STR1## are disclosed wherein aryl is an aromatic or heteroaromatic system, n is zero through 5; R and R(1), are hydrogen, or loweralkyl; W is hydrogen, (hetero)-(aryl)-loweralkyl; Z is hydrogen, CH.sub.2 OR(2.sub.), CHO, (CO)OR(2), (CO)NR(2).sub.2.
Processes for the preparation of compound I are also disclosed.
Compounds I are suitable for the treatment of disorders of the cardiovascular system, for example of hypertension, of cardiac insufficiency or of disturbances of blood flow in the coronary systems such as, for example, angina. Disturbances of cerebral and peripheral blood flow are likewise influenced beneficially. Furthermore, compounds I are able to influence smooth-muscle organs such as uterus, bronchi, intestines and biliary system, the urinary tract (ureter, bladder and urethra) in the sense of spasmolysis. They are therefore also suitable for the treatment of diseases associated with spasms of these organs, for example for the treatment of premature labor in pregnancy, of ureteral or biliary colic, of obstructive airway diseases such as asthma, of disturbances of intestinal motility such as, for example, of irritable colon or of bladder incontinence. Additionally, compounds of formula 1 can serve as anticonvulsants in the treatment of epilepsy.

REFERENCES:
patent: 4312875 (1982-01-01), Lesher et al.
V. H. Wissman et al., Angew. Chemie 1980, 92(2), 129-130.
J. Org. Chem. 1980, 45, "Photochemical Syntheses of 1,2-Diazepines. 11.1 Regiospecific Synthesis of 1,2-Dihydro-1,2-diazepin-3-ones", pp. 5095-5100.

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