Arylbicyclooctanes as inhibitors of leukotriene biosynthesis

Details Arylbicyclooctanes as inhibitors of leukotriene biosynthesis Arylbicyclooctanes as inhibitors of leukotriene biosynthesis

1993-07-20

1995-10-17

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546152, 546157, 546158, C07D40704, C07D40904, C07D21522, A61K 3147

Patent

active

054592712

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis and allograft rejection and in preventing the formation of atherosclerotic plaques.

REFERENCES:
patent: 5134148 (1992-07-01), Crawley et al.

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