Organic compounds -- part of the class 532-570 series – Organic compounds – Azo
Patent
1992-10-22
1994-05-10
Lee, Mary C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Azo
534768, 534770, 436 74, 436 79, C09B 2944, G01N 3122, G01N 3352
Patent
active
053108884
ABSTRACT:
Disclosed are arylazo chromoionophores characterized by the formula: ##STR1## wherein X is hydrogen or a monovalent cation, Y is H or methoxy and R is a ringed aromatic organic structure which affects the optical absorption properties of the compounds. Also disclosed is a method for the detection of calcium ion using these compounds.
REFERENCES:
patent: 4603209 (1986-07-01), Tsien et al.
patent: 4689432 (1987-08-01), Tsien et al.
patent: 4795712 (1989-01-01), Toner et al.
patent: 4806604 (1989-02-01), Tsien et al.
patent: 5141627 (1992-08-01), Tsien et al.
Grynkiewicz et al., "A New Generation of Ca.sup.2+ Indicators with Greatly Improved Fluorescence Properties", J. Biol. Chem. 260(6):3440-3450 (1985).
Tsien, "New Calcium Indicators and Buffers with High Selectivity against Magnesium and Protons" Biochemistry 19:2396-2404 (1980).
Bloczynski Michael L.
Boecker Thomas
Corey Paul F.
Jeffers Jerome L.
Lee Mary C.
Miles Inc.
Powers Fiona T.
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