Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-04-18
1991-08-13
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546 13, 546241, 546343, 548405, 548491, 548565, 548570, C07B 4900, C07B 3702, C07D21122, C07D20708
Patent
active
050398024
ABSTRACT:
The chiral catalyst of general structure 1, or its enantiomer ##STR1## is prepared by treating the corresponding N-carboxy anhydride of structure 2 ##STR2## with an aryl metal, especially a phenyl metal such as an aryl magnesium halide, aryl lithium, aryl zinc or aryl cesium, to form a 1,1-diaryl-methanol of structure 3 ##STR3## followed by treatment with a compound of structure, 4 ##STR4## The catalyst, wherein R is aromatic, is novel and in some cases superior to the catalyst wherein R is alkyl or aralkyl in directing the chirality of borane-dimethyl sulfide reductions of ketones to secondary alcohols.
REFERENCES:
Enders et al., Org. Synth., Col. vol. 6, 542-549.
Corey et al., J. Amer. Chem. Soc., 1987, 109, 7925-7926.
Kapfhammer et al., Hoppe-Seyler Zeit Physiol Chem. 1933.233, 43-52.
Corey et al., J. Org. Chem. 1988, 53, 2861-2863.
Corey et al., J. Amer. Chem. Soc. 1987 109, 5551-5553.
Enders et al., Bull. Soc. Chem. Belg., 1988, 97, 691-704.
Corey et al., Tet. Letters, 1989, 30 6375-6278.
Blacklock Thomas J.
Jones Todd K.
Mathre David J.
Xavier Lyndon C.
Berch Mark L.
DiPrima Joseph F.
Merck & Co. , Inc.
Nicholson William H.
Perrella Donald J.
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