Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-02-06
1993-06-01
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5483531, A61K 31415, C07D23322
Patent
active
052160084
ABSTRACT:
The present invention is directed to a new class of arylalkoxyphenoxy-imidazoline compounds and their use for the treatment of depression, anxiety, hypertension, and migraine headaches.
REFERENCES:
patent: 5134154 (1992-07-01), Freedman et al.
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van der Heyden et al., abstract of "The Effects of Serotonergic Drugs in a Behavioural Model of Depression," Psychopharmacology 101 Supp., S58 (1990).
Yagaloff et al., "Serotonin 5-HT.sub.1C receptors are expressed at high density on choroid plexus tumors from transgenic mice," Brain Research, 385, 389-394 (1986).
Curzon et al., "m-CPP: a tool for studying behavioural responses associated with 5-HT.sub.1C receptors," TiPS 11, 181-2 (1990).
Glover et al., "Can the vascular and neurogenic theories of migraine finally be reconciled?" Trends in Pharmacological Sciences including Toxicological Sciences, TiPS vol. 10, Jan. 1989.
Fozard et al., "5-HT.sub.1C receptor activation: a key step in the initiation of migraine?" TiPS vol. 10, Aug. 1989.
Baron Bruce M.
Dudley Mark W.
Freedman Jules
Collier Kenneth J.
Lee Mary C.
Merrell Dow Pharmaceuticals Inc.
Miltenberger Lenora A.
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