Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1982-07-09
1986-11-18
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
568335, 560105, C07D31906, C07C 6976
Patent
active
046237364
ABSTRACT:
In preparing arylalkanoic acids, e.g. ibuprofen or naproxen, via the conversion of the selected .alpha.-haloketal derivative of a 1-haloethyl aryl ketone to the haloalkyl ester of the arylalkanoic acid using a zinc salt catalyst the improvement comprising reacting a ring-substituted 6-membered ring ketal of the selected 1-haloethyl C.sub.6 -C.sub.12 -aryl ketone with a soluble zinc carboxylate salt to form the corresponding 3-haloalkyl arylalkanoic acid ester. The ester is converted to the alkali metal salt of the acid with base in an aqueous/water insoluble organic liquid mixture and the crude salt is converted to the corresponding acid in an aqueous/water insoluble solvent mixture for the acid, the organic solution of the acid is washed with a pH 7.0 to 8.0 buffer solution, and the arylalkanoic acid product is separated from the mother liquor which mother liquor is recycled to the alkali metal arylalkanoate salt forming step of the process to accumulate and recover the arylalkanoic acid values which remained in the mother liquor.
Amin Sanjay I.
Walker Jerry A.
Killos Paul J.
Reynolds John T.
The Upjohn Company
LandOfFree
Arylalkanoic acid process improvement does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Arylalkanoic acid process improvement, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arylalkanoic acid process improvement will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1618430