Aryl thiopyrano[4,3,2-cd]indoles as inhibitors of leukotriene bi

Details Aryl thiopyrano[4,3,2-cd]indoles as inhibitors of leukotriene bi Aryl thiopyrano[4,3,2-cd]indoles as inhibitors of leukotriene bi

1992-06-29

1994-05-24

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546270, A61K 3144, C07D49508

Patent

active

053148983

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of the 5-lipoxygenase enzyme and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, psoriasis, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.

REFERENCES:
Wade Jr. Organic Chemistry 1987 Prentice-Hall, Inc. p. 349.
Zeffren et al. The Study of Enzyme Mechanism p. 87, 1974.
Su et al., C.A. 101(g): 72492p 1984.
Kozikowski et al., Amer. Chem. Soc., 104, 7622-7626, 1982.

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