Aryl thiopyrano[2,3,4-C,D]indoles as inhibitors of leukotriene b

Details Aryl thiopyrano[2,3,4-C,D]indoles as inhibitors of leukotriene b Aryl thiopyrano[2,3,4-C,D]indoles as inhibitors of leukotriene b

1992-11-19

1994-05-24

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546270, A61K 3140, A61K 3144, C07D40112

Patent

active

053149009

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of 5-lipoxygenase and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, psoriasis, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.

REFERENCES:
Su et al., Abstract; Synthesis of Chuangxinmycin Derivatives, Shanghai Inst. Pharm. Ind.
Kozikowski, et al. J. Am. Chem. Soc., 104, pp. 7622-7626 (1982).
Unangst et al. J. Med Chem, 32, pp. 1360-1366 (1989).

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