Aryl thiophene derivatives as PDE IV inhibitors

Details Aryl thiophene derivatives as PDE IV inhibitors Aryl thiophene derivatives as PDE IV inhibitors

1998-09-28

2000-03-07

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514336, 514438, 514444, 544296, 544300, 5462804, 549 59, 549 78, 549 79, A61K 31505, A61K 3144, A61K 3138, C07D40300, C07D40900

Patent

active

060340894

ABSTRACT:
The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). ##STR1## The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula I.

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