Aryl sulfonamides

Details Aryl sulfonamides Aryl sulfonamides

2004-05-13

2008-09-02

Chang, Celia (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C546S271400, C514S235200, C514S340000

Reexamination Certificate

active

07420055

ABSTRACT:
Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.

REFERENCES:
patent: 2997368 (1961-08-01), Barent et al.
patent: 3121103 (1964-02-01), Keller et al.
patent: 3344183 (1967-09-01), Reeder et al.
patent: 3442946 (1969-05-01), Keller et al.
patent: 3534062 (1970-10-01), Wright et al.
patent: 4166452 (1979-09-01), Generales, Jr.
patent: 4256108 (1981-03-01), Theeuwes
patent: 4265874 (1981-05-01), Bonsen et al.
patent: 4372975 (1983-02-01), Mouzin et al.
patent: 4954518 (1990-09-01), Takano et al.
patent: 4992091 (1991-02-01), Vinogradoff et al.
patent: 4997940 (1991-03-01), Vinogradoff et al.
patent: 5021591 (1991-06-01), Vinogradoff et al.
patent: 5071468 (1991-12-01), Astles et al.
patent: 5093364 (1992-03-01), Richards et al.
patent: 5155121 (1992-10-01), Niewohner
patent: 5163995 (1992-11-01), Van Heertum et al.
patent: 5185348 (1993-02-01), Niewohner et al.
patent: 5217521 (1993-06-01), Durr
patent: 5338755 (1994-08-01), Wagnon et al.
patent: 5481005 (1996-01-01), Wagnon et al.
patent: 5541186 (1996-07-01), Breu et al.
patent: 5571775 (1996-11-01), Van Heertum
patent: 5589478 (1996-12-01), Yamada et al.
patent: 5780488 (1998-07-01), Bergman et al.
patent: 5973148 (1999-10-01), Ringer et al.
patent: 6136971 (2000-10-01), Harrington et al.
patent: 6200995 (2001-03-01), De la Brouse-Elwood
patent: 6297195 (2001-10-01), Gesing et al.
patent: 6297239 (2001-10-01), deSolms et al.
patent: 6316450 (2001-11-01), Bromidge et al.
patent: 6403607 (2002-06-01), Hidaka et al.
patent: 6432624 (2002-08-01), Kikuchi et al.
patent: 6653332 (2003-11-01), Jaen et al.
patent: 2002/0009116 (2002-01-01), Kobayashi et al.
patent: 2002/0012680 (2002-01-01), Patel
patent: 2002/0013314 (2002-01-01), Zhu et al.
patent: 2002/0037905 (2002-03-01), Dahl
patent: 2002/0037928 (2002-03-01), Jaen et al.
patent: 2002/0065303 (2002-05-01), Zhu et al.
patent: 2002/0072530 (2002-06-01), Zhu et al.
patent: 2002/0103202 (2002-08-01), Pinto
patent: 2003/0060460 (2003-03-01), Ohuchida et al.
patent: 2003/0139390 (2003-07-01), McGee et al.
patent: 561703 (1975-05-01), None
patent: 3544409 (1986-10-01), None
patent: 3825041 (1990-02-01), None
patent: 0 015 214 (1980-09-01), None
patent: 0 526 348 (1993-02-01), None
patent: 556673 (1993-02-01), None
patent: 0 613 894 (1994-09-01), None
patent: 884847 (1961-12-01), None
patent: 1332697 (1973-10-01), None
patent: WO 93/03013 (1993-02-01), None
patent: WO 94/20142 (1994-09-01), None
patent: WO 95/33462 (1995-12-01), None
patent: WO 96/08483 (1996-03-01), None
patent: WO 97/28129 (1997-08-01), None
patent: WO 98/11218 (1998-03-01), None
patent: WO 98/28270 (1998-07-01), None
patent: WO 98/50029 (1998-11-01), None
patent: WO 99/17777 (1999-04-01), None
patent: WO 99/32433 (1999-07-01), None
patent: WO 99/38845 (1999-08-01), None
patent: WO 99/42465 (1999-08-01), None
patent: WO 99/55324 (1999-11-01), None
patent: WO 99/55663 (1999-11-01), None
patent: WO 00/05214 (2000-02-01), None
patent: WO 00/62778 (2000-10-01), None
patent: WO 01/00579 (2001-01-01), None
patent: WO 01/09097 (2001-02-01), None
patent: WO 01/17971 (2001-03-01), None
patent: WO 01/19788 (2001-03-01), None
patent: WO 01/19798 (2001-03-01), None
patent: WO 01/32646 (2001-05-01), None
patent: WO 01/56607 (2001-08-01), None
patent: WO 01/56989 (2001-08-01), None
patent: WO 01/57003 (2001-08-01), None
patent: WO 01/57020 (2001-08-01), None
patent: WO 01/60319 (2001-08-01), None
patent: WO 02/00633 (2002-01-01), None
patent: WO 02/18326 (2002-03-01), None
patent: WO 02/30358 (2002-04-01), None
patent: WO 02/054867 (2002-07-01), None
patent: WO 02/055501 (2002-07-01), None
patent: WO 02/059080 (2002-08-01), None
patent: WO 03/099773 (2003-12-01), None
patent: WO 2005/004810 (2005-01-01), None
Cohen et al. “cytokine function . . . ” CA 125:31527 (1996).
Youn et al. “Blocking . . . ” CA 135:613109 (2001).
Oba et al. “MIP-1alpha . . . ” CA 142:461958 (2005).
IMS R&D Fucus “Chemokine receptor antagonist . . . ” Sep. (2006).
Tan et al. “All roads lead to . . . ” SciSearch 15762026 (2006).
ESPICOM “GSK/chemocyntryx . . . ” Espicom pharm$Med Device News (2006).
Burns “Composition and methods . . . ” CA 139:17596 (2003).
Berman et al., Immunol.Invest., 17, pp. 625-677, 1988.
Campbell, et al.,J. Exp. Med., 195(1), pp. 135-141, 2002.
Dahinden, et al.,J. Exp. Med., 179, pp. 751-756, 1994.
Dannhardt, et al., 37Eur.J.Med.Chem., pp. 147-161, 2002.
Davidson et al.,J Exp Med., 184, pp. 241-251, 1996.
Kavanaugh et al.,J. Immunol., 146, pp. 4149-4156, 1991.
Kontoyiannis et al.,Immunity, 10, pp. 387-398, 1999.
Kosiewicz et al.,J Clin Invest., 107(6), pp. 695-702, 2001.
Kunkel, et al.,J. Exp. Med. 192(5), pp. 761-767, 2000.
Lothrop et al.,J.Amer.Chem.Coc., CODEN:JACSAT, 63, pp. 2564-2567, 1941.
Murphy,Rev. Immun., 12, pp. 593-633, 1994.
Neote, et al.,Cell, 72, pp. 415-425, 1993.
Panwala, et al.,J Immunol., 161, pp. 5733-5744, 1998.
Papadakis, et al.,J. Immunol., 165, pp. 5069-5076, 2000.
Powrie et al.,Int Immunol., 5(11), pp. 1461-1471, 1993.
Qiuping Z et al.,Cancer Res., 63, pp. 6469-6477, 2003.
Schaarschmidt; Herzenberg, ChemBer., CODEN:CHBEAM, 53, pp. 1388-1399, 1920.
Schall,Cytokine, 3, pp. 165-183, 1991.
Schall, et al.,Curr. Opin. Immunol., 6, pp. 865-873, 1994.
SciFinder Search Results (Feb. 19, 2004).
SciFinder Search Results (Feb. 20, 2004).
Silvestri et al.,Medicinal Chemistry Research, 11(4), pp. 195-218, 2002.
Street et al., Journal of Chemical Research, Synopses, (5), pp. 154-155, 1987.
Targan et al.,N Engl J Med., 337(15), pp. 1029-1035, 1997.
Uehara, et al.,J. Immunol, 168(6), pp. 2811-2819, 2002.
Ullmann; Bleier, Chem.Ber., CODEN:CHBEAM, 35, pp. 4273-4280, 1902.
Van Riper, et al.,J. Exp. Med., 177, pp. 851-856, 1993.
Wurbel, et al.,Blood, 98(9), pp. 2626-2632, 2001.
Youn BS, et al., Apoptosis, 7, pp. 271-276, 2002.
Zaballos, et al.,J. Immunol., 162, pp. 5671-5675, 1999.
Science IP Search Report (Mar. 1, 2005).
Search Report (Sep. 3, 2002).

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