Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-08-22
1991-03-12
Lee, Mary C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549 52, 549 55, 546274, 548525, C07D33374
Patent
active
049994360
ABSTRACT:
Aryl substituted thiophenes 3-ols, its dihydro derivatives, 1-oxide and 1,1-dioxide analogs, as well as aryl substituted furans, are 5-lipoxygenase inhibitors useful in the treatment of inflammation and other leukotriene-mediated diseases.
REFERENCES:
patent: 3644399 (1972-02-01), Brown et al.
patent: 3655692 (1972-04-01), Tsung-Ying et al.
patent: 3892774 (1975-07-01), Ebnother et al.
patent: 3929833 (1975-12-01), Krieger et al.
patent: 4174405 (1979-11-01), Relyea et al.
patent: 4381311 (1983-04-01), Haber
patent: 4432974 (1984-02-01), Haber
patent: 4500520 (1985-02-01), Haber
patent: 4645777 (1987-02-01), Burkart et al.
patent: 4645842 (1987-02-01), Corey
patent: 4663344 (1987-05-01), Durette et al.
patent: 4704460 (1987-12-01), Corey
Shen et al., "The Development of Antiasthmatic Drugs", Part III, ed. D. R. Buckle et al. Butterworth Publishers, Kent England 1983, pp. 315-317 and 331-334.
Hortough, Thiophene and Derivatives, (1952), p. 472.
Fiesselman, et al., Unknown Journal, vol. 89, Nov. 8, 1956.
K. Buggle, et al. J. C. S. Perkin I. pp. 2630-2634 (1972).
B. Hedegaard, et al., Tetrahedron, vol. 77 pp. 3853 to 3859, (1971). Wilkerson, et al., Pharm. Res. and Dev. Div., DuPont and Company, Wilmington, Del. (1985).
Myers et al., Pharm. Res. and Dev. Div., DuPont and Co., Wilmington, Del. (1985).
D. R. Robinson et al., J. Exp. Med, vol. 163, 1986, pp. 1509-1517.
B. Samuelsson, Science, vol 220 pp. 568-575, (1983).
D. M. Bailey Annual Repts in Med. Chem., pp. 203-217, (1982).
Tesfay, B. et al., J. C. S. Perkins I, pp. 1147-1150 (1978).
Tesfay B. et al., J. C. S. Perkin I, pp. 2276-2281 (1979).
Hartough, Chem of Heterocyclic Compounds (1952) pp. 52-54.
Chem. Abst., Parnes, vol. 90, (1979) 87166p.
Chem. Abst., Kalantar, vol. 58 (1963) 11146b.
Allison Debra L.
Caldwell Charles G.
Rupprecht Kathleen
Witzel Bruce E.
Grassler Frank P.
Haley Jacqueline
Lee Mary C.
Merck & Co. , Inc.
Meredith Roy D.
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