Aryl-substituted pyrimidine sulphonamide compounds as endothelin

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514274, 544316, 544318, 544335, A01N 4354, A61K 31505, C07D23902

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active

060839511

ABSTRACT:
Pyrimidine sulphonamide compounds of the following formula, ##STR1## wherein Q is a naphthyl or biphenyl group either unsubstituted or substituted with A.sup.1, and where A.sup.1, R.sup.1 and R.sup.2 are a variety of alkyl, aryl and cyclic moieties, as described in the specification hereof, which compounds are useful for the treatment of diseases or medical conditions such as hypertension, pulmonary hypertension, cardiac or cerebral circulatory disease and renal disease.

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Pages copied from a book of abstracts provided in an International Business Communications Conference entitled "Endothelin Inhibitors--Advances in Therapeutic Application and Development", Philadelphia, PA, Jun. 9-10, 1994, 33 pages.

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