Aryl substituted carbamate derivatives which are ACAT inhibitors

Details Aryl substituted carbamate derivatives which are ACAT inhibitors Aryl substituted carbamate derivatives which are ACAT inhibitors

1990-09-18

1992-08-25

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

544319, 544322, 546309, 560 29, 560 31, 560 32, C07C12500, C07C12502

Patent

active

051420945

ABSTRACT:
This invention relates to novel compounds which are ACAT inhibitors rendering them useful in lowering blood cholesterol levels. The compounds are carbamates represented by the general formula ##STR1## wherein Ar and Ar' represent phenyl, naphthyl or heteroaryl, each of which may be substituted; Z and W are hydrogen, aliphatic hydrocarbon, heterocyclic, aryl or carbocyclic containing groups.

REFERENCES:
patent: 4315861 (1982-02-01), Lugosi et al.
patent: 4482546 (1984-11-01), Takahashi et al.
Chemical Abstracts 82:45057h, 1975, p. 107.

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