Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-12-27
1988-05-31
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548524, 546190, 540596, 514212, 514316, 544 72, 560 42, 564165, 564223, A61K 3140, A61K 31455, C07D40310, C07D40110
Patent
active
047481846
ABSTRACT:
The present invention relates to new compounds of the formula ##STR1## wherein X is ##STR2## wherein R.sub.1 is hydrogen, lower alkyl, phenyl, benzyl, cinnamoyl, thiophene, furan, pyrrole, imidazole, pyrazole oxazole or thiazole; W is hydrogen or hydroxy; (Y).sub.A is positioned ortho to W and is an aminoloweralkyl having the formula --CH.sub.2 NR.sub.2 R.sub.3 where R.sub.2 and R.sub.3 are the same or different and may be lower alkyl or R.sub.2 and R.sub.3 may together with N form a pyrrolidine, piperidine or azepine ring, and A is 2; n and m are independently from 0 to 5; and R is straight or branched C.sub.1 -C.sub.10 alkyl, straight or branched C.sub.3 -C.sub.10 cycloalkyl, straight or branched C.sub.2 -C.sub.4 alkenyl or straight or branched C.sub.2 -C.sub.4 alkynyl, or a pharmaceutically acceptable salt thereof.
These compounds are useful in the treatment of various cardiac arrhythmias.
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Boucherle, Chimie Therapeutique (1967) No. 6, pp. 410-414.
Li, et al., Chemical Abstracts, vol. 92 (1980), Entry 121950t.
Sun, et al., Yao Hsueh Hsueh Pao., vol. 16(8) (1981), pp. 564-570.
Black Lawrence A.
Matier William L.
Stout David M.
Daus Donald G.
E. I. Du Pont de Nemours and Company
Fato Gildo E.
Teoli, Jr. William A.
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