Aryl substituted aminomethyl benzene derivatives

Details Aryl substituted aminomethyl benzene derivatives Aryl substituted aminomethyl benzene derivatives

1988-04-07

1991-10-22

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 514316, 514317, 514318, 514326, 514331, 514371, 514372, 514377, 514380, 514397, 514398, 514407, 514447, 514472, 514620, 514624, 514625, 514627, 514629, 514630, 540596, 540597, 540602, 540603, 540610, 546186, 546187, 546190, 548195, 548214, 548233, 548245, 548246, 548336, 548337, 548338, 548339, 548374, 548377, 548524, 549 63, 549480, 564164, 564165, 564168, 564189, 564190, 564204, 564207, C07D21100, C07D21130, C07D27704, C07D26304, C07D20700, C07D23366, C07D48700, A61K 31445, A61K 3140, A61K 31395

Patent

active

050596209

ABSTRACT:
The present invention relates to new compounds of the formula ##STR1## wherein X is ##STR2## wherein R.sub.1 is hydrogen, lower alkyl, phenyl, benzyl, cinnamoyl, thiophene, furan, pyrrole, imidazole, pyrazole oxazole or thiazole; W is hydrogen or hydroxy; (Y).sub.A is positioned ortho to W and is an aminoloweralkyl having the formula --CH.sub.2 NR.sub.2 R.sub.3 where R.sub.2 and R.sub.3 are the same or different and may be lower alkyl or R.sub.2 and R.sub.3 may together with N form a pyrrolidine, piperidine or azepine ring, and A is 2; n and m are independently from 0 to 5; and R is straight or branched C.sub.1 -C.sub.10 alkyl, straight or branched C.sub.3 -C.sub.10 cycloalkyl, straight or branched C.sub.2 -C.sub.4 alkenyl or straight or branched C.sub.2 -C.sub.4 alkynyl, or a pharmaceutically acceptable salt thereof.
These compounds are useful in the treatment of various cardiac arrhythmias.

REFERENCES:
patent: 4466965 (1984-08-01), Stout
patent: 4562201 (1985-12-01), Stout
patent: 4755527 (1988-07-01), Stout

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