Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-i

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514361, 514363, 514375, 514381, 514383, 514387, 514388, 548126, 548154, 548217, 548218, 548252, 5482624, 5483027, 5483031, C07D48704, A61K 31435

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active

055524222

ABSTRACT:
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

REFERENCES:
patent: 4064260 (1977-12-01), Cherkofsky et al.
patent: 4175127 (1979-11-01), Bender et al.
patent: 4263311 (1981-04-01), Bender
M. A. Salama, et al., Phosphorus and Sulfur, 1988, 35, pp. 83-88 "Synthesis and Reactions of 4,5-Diaryl-2-Mercaptoimidazoles".
H. A. Hammouda, et al., Gazzetta Chimica Italiana, 1984, 114, pp. 201-204 "Reactions with 4,5-Diphenylimidazolidine-2-Thione . . . ".
I. Lantos, et al., J. Med. Chem., 1984, 27, pp. 72-75 "Antiinflammatory Activity of 5,6-Diaryl-2,3-dihydroimidazo[2,1-b]thiazoles . . .".
P. E. Bender, et al., J. Med. Chem., 1985, 28, pp. 1169-1177 "5,6-Diaryl-2,3-dihydroimidazo[2,1-b]thiazoles: A New Class of Immunoregulatory Antiinflammatory Agents".

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