Aryl spirolactam CGRP receptor antagonists

Details Aryl spirolactam CGRP receptor antagonists Aryl spirolactam CGRP receptor antagonists

2011-08-02

2011-08-02

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S284000, C548S407000

Reexamination Certificate

active

07989624

ABSTRACT:
The present invention is directed to compounds of Formula (I): where variables A1, A2, B, J, K, m, n, R4, R5a, R5b, R5cand X are as defined herein useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

REFERENCES:
patent: 7189722 (2007-03-01), Bell et al.
patent: 7192954 (2007-03-01), Bell et al.
patent: 7202251 (2007-04-01), Bell et al.
patent: 7390798 (2008-06-01), Williams et al.
patent: 7625901 (2009-12-01), Wood et al.
patent: 7629338 (2009-12-01), Wood et al.
patent: 7659300 (2010-02-01), Bell et al.
patent: 7696192 (2010-04-01), Bell et al.
patent: 2004/0063735 (2004-04-01), Chaturvedula et al.
patent: 2006/0189600 (2006-08-01), Bell et al.
patent: WO2004082605 (2004-09-01), None
patent: WO2004082678 (2004-09-01), None
patent: WO2004083187 (2004-09-01), None
patent: WO2004087649 (2004-10-01), None
patent: WO 2006/029153 (2006-03-01), None
patent: WO 2006/031610 (2006-03-01), None
patent: WO2006029153 (2006-03-01), None
patent: WO2006031491 (2006-03-01), None
Bell, Ian, et al.,—Abstract—AN 2006:269508.
Supplementary European Search Report, dated Dec. 30, 2009.
Pinder, et al., “2-Aminoindan-2-carboxylic Acids. Potential Tyrosine Hydroxylase Inhibitors,” Journal of Medicinal Chemistry, vol. 14, No. 9, 1971, pp. 892-893.

Affiliated with

Also associated with

Rating

Aryl spirolactam CGRP receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aryl spirolactam CGRP receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aryl spirolactam CGRP receptor antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2758021