Aryl pyrimidine derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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540593, 540552, 544320, 544321, 544330, 544323, 544331, 544324, 544332, 544 51, 544 52, 5142305, 514211, 514213, 514272, 514273, C07D40304, C07D23942, A61K 31505, A61K 3155

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active

058639241

ABSTRACT:
The disclosed pyrimidine derivatives, and pharmaceutically acceptable salts and N-oxides thereof, exhibit useful pharmacological properties, in particular use as selective 5HT.sub.2B -antagonists. The invention is also directed to formulations and methods for treatment.

REFERENCES:
patent: 3965101 (1976-06-01), Yale et al.
patent: 4543248 (1985-09-01), Stringfellow et al.
patent: 4619933 (1986-10-01), Stringfellow et al.
patent: 4665077 (1987-05-01), Stringfellow et al.
patent: 5002951 (1991-03-01), Stringfellow et al.
patent: 5147876 (1992-09-01), Mizuchi et al.
patent: 5223505 (1993-06-01), Hargreaves et al.
patent: 5698444 (1997-12-01), Baez et al.
patent: 5705519 (1998-01-01), Audia et al.
patent: 5736544 (1998-04-01), Audia et al.
Essawy et al., Egypt. J. Chem. (1994), vol. 37, No. 4, pp. 423-431, "Synthesis and Reactions of 2-Amino-4-Aryl-6-(2'-Methoxynaphthyl)Pyrimidines".
Mokrosz, J.L., et al., Pharmazie (1994) vol. 49, No. 11, pp. 801-806, "Structure-activity relationship studies of CNS agents. Part 14: Structural requirementfor the 5-HT1A and 5-HT2A receptor selectivity of simple 1-(2-pyrimidinyl) piperazine derivatives".
Mariella et al., J. Org. Chem. (1960), vol. 25, pp. 647-648, "Preparation of Various Substituted Pyrimidines".
Budesinsky et al., Collection Czechoslav. Chem Commun. (1961), vol. 26, pp. 2865-2870, "Uber Die Darstellung Von 2-Sulfanilamido-4-Methylpyrimidinen Mit Einem Heterocyclischen Substituenten in 6-Stellung".
Zagulyaeva et al., Izv. Sib. Otd. Akad. Nauk SSSR, Ser. Khim. Nauk (1990), vol. 4, pp. 27-31, "Synthesis of Methoxyalkyl Substituted 2-Aminopyrimidines From .Gamma.-Methoxyalkynyl Ketones".
Essawy et al., Egypt. J. Chem. (1994), vol. 37, No. 4, pp. 423-431, "Synthesis and Reactions of 2-Amino-4-Aryl-6-(2'-Methoxynaphthyl)Pyrimidines".
Hoyer et al., "International Union of Pharmacology Classification of Receptors for 5-Hydroxytryptamine (Serotonin)," Pharmacological Reviews 46(2):157-203 (1994).
Martin et al., "Receptors for 5-Hydroxytryptamine: Current Perspectives on Classification and Nomenclature," Neuropharmacology 33(34):261-273 (1994).

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