Aryl phosphate derivatives of AZT having anti-HIV activity

Details Aryl phosphate derivatives of AZT having anti-HIV activity Aryl phosphate derivatives of AZT having anti-HIV activity

2006-07-04

2006-07-04

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

C514S086000, C544S105000, C544S118000, C544S243000, C544S244000

Reexamination Certificate

active

07071176

ABSTRACT:
Aryl phosphate derivatives of d4T with para-bromo substitution on the aryl group show markedly increased potency as anti-HIV agents without undesirable levels of cytotoxic activity. In particular, these derivatives are potent inhibitors of HIV reverse transcriptase. In a preferred aspect of the present invention, the phosphorus of the aryl phosphate group is further substituted with an amino acid residue that may be esterified or substituted, such as a methoxy alaninyl group.

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