Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1974-05-03
1976-05-11
Demers, Arthur P.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260269, 260298, 2603131, 2604299, 260439R, 260473R, 260469, 260515R, 260526N, 260558R, 260559R, 424287, 424289, 424295, 424308, 424317, 424324, C07C 6300
Patent
active
039563740
ABSTRACT:
Novel 4-phenyl-4-substituted-5-oxo-7-aryl-heptanoic acids are prefaced by either of two synthetic processes. The first method involves the reaction of a 4-phenyl-4-substituted-5-oxo-hexanoic acid with an arylcarboxyaldehyde. The second method involves reaction of an arylcarboxaldehyde with an appropriate ketone, treatment of the product with an acrylic acid ester, followed by hydrolysis of the resulting ester. The compounds of the invention are prostaglandin antagonists and are particularly useful as topical anti-inflammatory agents.
REFERENCES:
patent: 3042714 (1962-07-01), Schultz et al.
Krauch et al., Organic Name Reactions, John Wiley & Sons, N.Y., N.Y., 1964 p. 96.
Cragoe, Jr. Edward J.
Halczenko Wasyl
Shepard Kenneth L.
Arther Thomas E.
Demers Arthur P.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Westlake, Jr. Harry E.
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