Aryl oxo-alkynoates as 5-lipoxygenase inhibitors

Details Aryl oxo-alkynoates as 5-lipoxygenase inhibitors Aryl oxo-alkynoates as 5-lipoxygenase inhibitors

1985-03-27

1986-11-25

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514545, 560 47, 560 48, 560 51, 560 53, A61K 3124, C07C 69738

Patent

active

046249648

ABSTRACT:
Aryl oxo-alkynoates are 5-lipoxygenase inhibitors, making them useful for the treatment of inflammation, chronic obstructive lung disease or psoriasis. These compounds have the formula: ##STR1## wherein n is 1-12;

REFERENCES:
patent: 3409424 (1968-11-01), Brewbaker
patent: 3592922 (1971-07-01), Gier et al.
patent: 3812262 (1974-05-01), Chodnekar et al.
patent: 3839455 (1974-10-01), Scherm et al.
patent: 4405810 (1983-09-01), Blythin et al.
Herrmann et al., J. Am. Chem. Soc., vol. 101, No. 6, pp. 1544-1549, (1979).
Kulkarni et al., Chemical Abstracts, vol. 70, No. 96356q, (1969).
Sakurai et al., Chemical Abstracts, vol. 69, No. 94792j, (1969).
Chan et al., J. Org. Chem. vol. 43, No. 18, pp. 3435-3440, (9/1/78).
Pirkle et al. J. Org. Chem., vol. 43, No. 11, pp. 2091-2093, (5/26/78).
T. Fukumaru et al. in Agr. Biol. Chem., 39, 519 (1975).
M. M. Midland et al. in J. Am. Chem. Soc., 102, 867 (1980).
H. Durr et al. in Justus Liebigs Ann Chem., 7, 1140 (1974).
H. Saikachi et al., Chem. Pharm. Bull., 27, 2857 (1979).
J. Bastide et al., Tetrahedron Lett., 41, 4225 (1972).
Harland et al., Chemical Abstract, vol. 99, No. 105072x, (1983).

Affiliated with

Also associated with

Rating

Aryl oxo-alkynoates as 5-lipoxygenase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aryl oxo-alkynoates as 5-lipoxygenase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aryl oxo-alkynoates as 5-lipoxygenase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1158724