Aryl or heteroaryl fused imidazole compounds as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

07141580

ABSTRACT:
This invention provides a compound of the formula (I):or the pharmaceutically acceptable salts thereof, wherein Y1, Y2, Y3and Y4are independently selected from N, CH, etc.; R1is H, C1-8alkyl, etc.; Q1is a 5–12 membered monocyclic or bicyclic aromatic ring optionally containing up to 4 heteroatoms selected from O, N and S, etc.; A is a 5–6 membered monocyclic aromatic ring optionally containing up to 3 heteroatoms selected from O, N and S, etc.; B is C1-6alkylene optionally substituted with an oxo group, etc.; W is NH, O, etc.; R2is H, C1-4alkyl, etc.; Z is a 5–12 membered monocyclic or bicyclic aromatic ring optionally containing up to 3 heteroatoms selected from O, N and S, etc.; L is halo, C1-4alkyl, etc.; m is 0, 1 or 2; R3and R4are independently selected from H and C1-4alkyl; R5is H, C1-4alkyl, etc.; Q2is a 5–12 membered monocyclic or bicyclic aromatic ring or tricyclic ring optionally containing up to 3 heteroatoms selected from O, N and S, etc. These compounds are useful for the treatment of medical conditions mediated by prostaglamndin such as pain, fever or inflammation, etc. This invention also provides a pharmaceutical composition comprising the above compound.

REFERENCES:
patent: 0405391 (1991-01-01), None
patent: 2330307 (1999-04-01), None
patent: WO 9947497 (1999-09-01), None
patent: WO 0021532 (2000-04-01), None
patent: WO 0021542 (2000-04-01), None
patent: 0064888 (2000-11-01), None
patent: WO 0064880 (2000-11-01), None
patent: 0250031 (2002-06-01), None
patent: 0250032 (2002-06-01), None
patent: 0250033 (2002-06-01), None
Golub et al., Science, vol. 286, Oct. 15, 1999, pp. 531-537.
Miyaura et al., The Journal of Biological Chemistry, vol. 275, No. 26, Jun. 30, 2000, pp. 19819-19823.
International Search Report, Jun. 6, 2002, PC23006A/DAM.

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