(Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their

Details (Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their (Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their

1987-07-28

1989-06-13

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514396, 514399, 514400, 548202, 548336, 548335, 548341, 548342, 548346, A61K 3138, A61K 31415, C07D40304

Patent

active

048393754

ABSTRACT:
This invention relates to novel (aryl or heteroaromatic methyl)-2,2'-1H-biimidazoles; to a process for their production comprising of reacting an appropriate alpha-brominated or alpha-chlorinated, substituted or non-substituted, methylated monoaromatic ring compound with 2,2'-bi-1H-imidazole in a solvent such as ethanol in the presence of a base such as sodium hydroxide under reflux conditions; and to pharmaceutical compositions and methods of treating hypertension with such compounds.

REFERENCES:
patent: 4670563 (1987-06-01), Jansen et al.
Matthews, D. P., et al., J. Org. Chem., 51 3328-3231 (1986).
Whitten, J. P., et al., J. Org. Chem., 51, 1891-1894 (1986).
Matthews, D. P., et al., Synthesis, 336, (1986).
(Exhibit A) Telex of Jan. 20, 1988 regarding Hungarian Appl. No. 4855/78.
(Exhibit B) Letter of Feb. 25, 1988 regarding Portuguese Appl. No. 83,799.

Affiliated with

Also associated with

Rating

(Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1277969