Aryl nitrone therapeutics for the treatment of inflammatory bowe

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514278, 514415, A61K 3115, A61K 3144, A61K 31405

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active

060839899

ABSTRACT:
Disclosed are methods for treating or preventing inflammatory bowel disease (IBD) using aryl nitrone compounds. Pharmaceutical compositions containing aryl nitrone compounds which are useful for the treatment or prophylaxis of IBD are also disclosed.

REFERENCES:
patent: 5036097 (1991-07-01), Floyd et al.
patent: 5292746 (1994-03-01), Carr et al.
patent: 5475032 (1995-12-01), Carney
patent: 5498778 (1996-03-01), Carr et al.
patent: 5532252 (1996-07-01), Carr et al.
Characterization of the radical trapping activity of a novel series of cyclic nitrone spin traps; Thomas et al. J.biol. Chem. (1996), 271(6), 3097-104.
Anana, RD et al. (1997) Snythesis and smooth-muscle calcium-channel effects of dialkyl 1,4-dihydro-2,6-dimethy-4-aryl-3,5-pyridinedicarboxylates containing a nitrone moiety in the 4-aryl substituent, Arch. Pharm. (Weinheim, Ger.) 330: 53-58.
Bonner, GF (1996) Current medical therapy for inflammatory bowel disease, Southern Medical Journal, 89: 556-566.
Buettner, GR (1987) ESR Parameters of Spin Adducts, Free Radical Biology, 3: 259-303.
Calkins, BM, Mendeloff, Al (1986) Epidemiology of Inflammatory Bowel Disease, Epidemiology Review 8: 60-90.
Cao, X. and Phillis, JW (1994) a-Phenyl-N-tert-butyl-nitrone Reduces Cortical Infarct and Edema in Rats Subjected to Focal Ischemia. Brain Res. 644: 267-272.
Carney, JM, Starke-Reed, PE Oliver, CN, Landrum, RW, Cheng, MS, Wu, JF and Floyd, RA (1991) Reversal or age-related increase in brain protein oxidation in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-.alpha.-phenylnitrone. Proc. Natl. Acad. Sci., 88: 3633-3636.
Castro, GA, Roy, SA, Stockstill, RD (1974) Trichinella Spiralis: Peroxidase Activity in Isolated Cells from the Rat Intestine, Exp. Parasitol., 36: 307-315.
Crotty, B. (1994) Ulcerative Colitis and Xenobiotic Metabolism, Lancet, 343:35-38.
Edamatsu,R, Mori,A., Packer, L (1995) The Spin Trap N-tert-.alpha.-phenyl-butylnitrone Prolongs the Life Span of the Senescence Accelerated Mouse, Biochem Biophys Res Comm 211: 847-849.
Elson, CO, Startor, RB, Tennyson, GS, Ridell, RH (1995), Experiemental Models of Inflammatory Bowel Disease, Gastroenterology, 109: 1344-1367.
Floyd, RA and Carney, J., Nitrone Radical Traps (NRTs) Protect in Experimental Neurodegenerative Diseases, in Neuroprotective Approaches to the Treatment of Parkinson's Disease and Other Neurodegenerative Disorders (Olanow, CW, Jenner, P and Youssim E, Eds.) Academic Press, New York, New York, in press.
Glickman, RM (1994) Inflammatory Bowel Disease in Harrison's Principles of Internal Medicine (McGraw Hill, New York, NY) Chapter 255: 1403-1416.
Grisham MB, MacDermott, RP, Deitch EA (1990), Oxidant Defence Mechanisms in the Human Colon, Inflammation, 14: 669-680.
Hamburger, SA, McCay, PB (1989) Endotoxin-Induced Mortality in Rats is Reduced by Nitrones, Circulatory Shock, 29: 329-334.
Hanauer, SB, Baert, F. (1994) Medical Therapy of Inflammatory Bowel Disease, Med Clin North Am, 78: 1413-1426.
Hanauer, B. (1993) Medical Therapy of Ulcerative Colitis, Lancet, 342: 412-417.
Harris, ML, Schiller, HJ, Reilly, PM, Donowitz, M, Grisham, MB, Bulkley (1992), Free Radicals and Other Reactive Oxygen Metabolites in Inflammatory Bowel Disease: Cause, Consequence or Epiphenomenom, Pharmacol. Ther., 53: 375-408.
Higa, A. McKnight, GW, Wallace, JL (1993) Attenuation of Epithelial Injury in Acute Experimental Colitis by Immunomodulators, Eur. J. Pharmacol. 239: 171-178.
Levin, B. (1992) Inflammatory Bowel Disease and Colon Cancer, Cancer (Supplement), 70:1313-1316.
MacDermott, RP (1994) Alterations in the Mucosal System in Ulcerative Colitis and Crohn's Disease, Med Clin North Am, 78: 1207-1231.
McKechnie, K., Furman, BL, Paratt JR (1986), Modification by Oxygen Free Radical Scavengers of the Metabolic and Cardiovascular Effects of Endotoxin Infusion in Conscious Rats, Circulatory Shock 19: 429-439.
Miyajima, T., Kotake, Y. (1995) Spin Trapping Agent, Phenyl N-Tert.sub.- Butyl Nitrone, Inhibits Induction of Nitric Oxide Synthase in Endotoxin-Induced Shock in Mice, Biochem Biophys Res Commun, 215: 114-121.
Novelli, GP (1992) Oxygen Radicals in Experimental Shock: Effects of Spin-Trapping Nitrones in Ameliorating Shock Pathophysiology, Critical Care Medicine, 20: 499-507.
Oliver, CN, Starke-Reed, PE, Stadtman, ER, Carney, JM and Floyd, RA (1990) Oxidative Damage to Brain Proteins, Los of Glutamine Synthetase Activity and Production of Free Radicals During Ischemia Induced Injry to Gerbil Brain. Proc. Natl. Acad. Sci. USA 87: 5144-5147.
Progrebniak, HW, Merino, MJ, Hahn, SM, Mitchell, JB, Pass, HI (1992) Spin Trap Salvage from Endotoxemia: The Role of Cytokine Down-Regulation, Surgery, 112: 130-139.
Thomas CE et al. (1996) Characterization of the radical trapping activity of a novel series of cyclic nitrone spin taps, Journal of Biological Chemistry, 271: 3097-3104.
Wallace, JA, MacNaughton, WK, Morris, GP, Beck PL (1989) Inhibition of Leulotriene Synthesis Markedly Accelerates Healing in a Rat Model of Inflammatory Bowel Disease, Gastroenterology, 95: 29-35.
Winrow, VR, Winyard, PG, Morris, CJ, Blake, DR (1993) Free radicals in Inflammation: Second Messengers and Mediators of Tissue Destruction, Br Med Bull 49: 506-522.
Yamada, T, Marshall, S, Specian, RD, Grisham, MB (1992) A Comparative Analysis of Two Models of Colitis in Rats, Gastroenterology, 102: 1524-1534.
Zhao, Q., Pahlmark, K., Smith, M.-J., and Siesjo, B. (1994) DelayedTreatment with the Spin Trap a-phenyl-n-tert-butyl nitrone (PBN) Reduces Infarct Size Following Transient Middle Cerebral Artery Occlusion in Rats. Acta Physiol. Scad. 152: 349-350.

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