Aryl N,N-bis cinnamamide compounds and their use as ultraviolet

Details Aryl N,N-bis cinnamamide compounds and their use as ultraviolet Aryl N,N-bis cinnamamide compounds and their use as ultraviolet

1984-06-25

1989-11-28

Warren, Charles E.

Drug, bio-affecting and body treating compositions

Topical sun or radiation screening, or tanning preparations

Aromatic acid or derivative containing

564155, 564158, 514616, 523508, 524217, 524220, 524225, 524226, A61K 31165, C07C10378, C07C10376

Patent

active

048836532

ABSTRACT:
An aryl N,N'-bis cinnamamide compound having a formula comprising: ##STR1## wherein x equals an integer from 0 to 3; y equals an integer from 0 to 2; z equals an integer from 0 to 2; each R is individually selected from the group consisting of a lower alkyl group having 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, a halo group, a nitro group, an aryl group having 6 to 18 carbon atoms, and a fused unsubstituted or substituted aromatic ring when x is 2 or 3; and each R' and R" is individually selected from the group consisting of a lower alkyl group having from 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, a halo group, a nitro group or an aryl group having from 6 to 18 carbon atoms. These compounds are useful as U.V. light absorbers in plastics and cosmetics (e.g. sunscreens).

REFERENCES:
patent: 3936418 (1976-03-01), Pond et al.
patent: 3941581 (1976-03-01), Teach
patent: 4049713 (1977-09-01), Spivack
patent: 4127586 (1978-11-01), Rody et al.
CA. 78:1361661(b), (1973).
CA. 69:67276n, (1968).
CA 45:7969e, (1951).
Altman et al., J. Pharm. Sci., 1972, 61(4), 610-613.
Cerbai et al., Gazz. Chim. Ital., 92, 420-427, (1962).

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