Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-art

Details Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-art Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-art

1993-11-08

1995-06-27

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514365, 514374, 514375, 548131, 548205, 548222, 548235, A61K 31415, A61K 3142, A61K 31425, C07D26332

Patent

active

054280486

ABSTRACT:
This invention relates to compounds which inhibit lipoxygenase in the metabolism of arachidonic acid and thus inhibits formation of leukotrienes which are implicated in inflammatory processes and bronchoconstriction and inhibits the oxidation of LDL which is implicated in formation of atherosclerotic plaque.
The compounds useful in this invention are represented by the formula: ##STR1## wherein: R.sup.2 is hydrogen, halogen or C.sub.1 -C.sub.6 alkyl; Y of O or S; R.sup.5 is hydrogen or methyl R.sup.6 is --NH.sub.2, --CH.sub.3 or --OCH.sub.3 ;

REFERENCES:
Reaven et al., Arteriosclerosis and Thrombosis 12(3), 318-21 (1992).
Steinberg, Amer J. of Cardiology 57, 16H-21H, (1986).
Carew, Schwenke and Steinberg, Proc. Natl. Acad. Sci. 84, 7725-29 (1987).
Nagano et al., Arteriosclerosis 9(4), 453-461 (1989).
Moskowitz, Medline Abs. #91080793, 1991.

Affiliated with

Also associated with

Rating

Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-art does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-art, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-art will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-287823