Aryl-n-hydroxyureas as inhbitors of 5-lipoxygenase and anti-arte

Details Aryl-n-hydroxyureas as inhbitors of 5-lipoxygenase and anti-arte Aryl-n-hydroxyureas as inhbitors of 5-lipoxygenase and anti-arte

1995-03-24

1996-07-30

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514365, 514374, 514375, A61K 31415, A61K 3142, A61K 31425

Patent

active

055412050

ABSTRACT:
This invention relates to compounds which inhibit lipoxygenase in the metabolism of arachidonic acid and thus inhibits formation of leukotrienes which are implicated in inflammatory processes and bronchoconstriction and inhibits the oxidation of LDL which is implicated in formation of atherosclerotic plaque.
The compounds useful in this invention are represented by the formula: ##STR1## wherein: R.sup.2 is hydrogen, halogen or C.sub.1 -C.sub.6 alkyl; Y of O or S;R.sup.5 is hydrogen or methyl

REFERENCES:
patent: 5428048 (1995-06-01), Malamas et al.
Reaven et al. Arteriosclerosis & Thrombosis 12(3) 318-21 1992.
Steinberg, Amer. J. of Cardiology 57, 16H-21H 1986.
Carew et al., Proc. Natl. Acad. Sci. 84 7725-29 1987.
Nagano et al., Arteriosclerosis 9(4) 453-461 1989.
Moskowitz, Medline Abs. #91080793, 1991.

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