Aryl N-alkylacridancarboxylate derivatives useful for chemilumin

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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435 28, 435 25, 435 4, 435968, 436172, C07D21906, C07D21902

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057506981

ABSTRACT:
Acridans which are reactable with a peroxidase and peroxide. The acridans are characterized by having an aromatic leaving group ArO which is a di- or polyhalosubstituted phenoxy group. The compounds are useful in assays where one member of a binding pair is linked to the peroxidase and for detecting the peroxidase. The method can also be used to detect hydrogen peroxide.

REFERENCES:
patent: 4927769 (1990-05-01), Chang
patent: 5145772 (1992-09-01), Voyta
patent: 5171668 (1992-12-01), Sugiyama
patent: 5206149 (1993-04-01), Oyama
patent: 5283334 (1994-02-01), McCapra
patent: 5438139 (1995-08-01), Sato et al.
patent: 5491072 (1996-02-01), Akhavan-Tafti
patent: 5521103 (1996-05-01), Zomer et al.
patent: 5523212 (1996-06-01), Akhavan-Tafti
patent: 5593845 (1997-01-01), Akhavan-TAfti
patent: 5594112 (1997-01-01), Sato et al.
Steenken, S., Photochem. Photobiol., 11, 279-283 (1970).
Hapiot, P., J. Moiroux, J. M. Saveant, J. Am. Chem. Soc., 112 (4), 1337-43 (1990).
Koper, N. W., S. A. Jonker, J. W. Verhoeven, Recl. Trav. Chim. Pays-Bas, 104(11), 296-302 (1985).
McCapra, F., Accts. Chem. Res., 9(6), 201-8 (1976).
McCapra, R., M. Roth, D. Hysert, K.A. Zaklika in Chemiluminescence and Bioluminescence, Plenum Press, New York, pp. 313-321 (1973).
McCapra, F., Prog. Org. Chem., 8, 231-277 (1971).
McCapra, F., Pure Appl. Chem., 24, 611-629 (1970).
Kinkel, T., H. Lubbers, E. Schmidt, P. Molz, H. J. Skripczyk, J. Biolumin. Chemilumin., 4, 136-139 (1989).
Zomer, G., J.F.C. Stavenuiter, Anal. Chim. Acta, 227, 11-19 (1989).
Law, S.-J., T. Miller, U. Piran, C. Klukas, S. Chang, J. Unger, J. Biolumin. Chemilumin., 4, 88-98 (1989).
Ii, M., H. Yoshida, Y. Aramaki, H. Masuya, T. Hada, M. Terada, M.Hatanaka, Y. Ichimori, Biochem. Biophys.Res.Comm., 193 (2), 540-5 (1993).
Thorpe, G., L. Kricka, in Biolum. and Chemilumin., New Perspectives, J. Scholmerich, et al., Eds., pp. 199-208 (1987).
Lundin,A., L. Hallander, in Biolumin. and Chemilumin., New Perspectives, J. Scholmerich, et al. Eds., pp. 555-558 (1987).
Vlasenko, S., A. Arefyev, A. Klimov, B. Kim, E. Gorovits, A. Osipov, E. Gavrilova, A. Yegorov, J. Biolumin.Chemilumin. 4,164-176 (1989).
Thorpe, G.H., et al., Clin. Chem., 31, 1335 (1985).
Matthews, J.A., et al., Anal. Biochem., 151,205 (1985).
Kricka, L. J., et al., Arch. Biochem. Biophys., 217, 674 (1983).
Goto, T., et al., Tetrahedron. Lett., 4299 (1969).
Sasamoto, K., et al., Chem. Pharm. Bull. 39 (2) 411-6 (1991).
Stott, R.A.W., et al., Biolumin. and Chemilumin. J.Scholmerich, et al, Eds.,pp.237-240 (1987).
Sinha, A., T. C. Bruice, J. Am. Chem. Soc., 106(23), 7291-2 (1984).
Colter, A. K., P. Plank, J. P. Bergsma, R. Lahti, A. A. Quesnel, A. G. Parsons, Can. J. Chem., 62(9), 1780-4 (1984).
Chupakhin, O.N., I.M. Sosonkin, A.I. Matern, G.N. Strogov, Dokl. Akad. Nauk SSSR, 250 (4), 875-7 (1980).
Knappe, W.R., J. Pharm. Sci., 67 (3), 318-20 (1978).
Digenis, G. A., S. Shakshir, M.A. Miyamoto, H. B. Kostenbauer, J. Pharm. Sci., 65 (2), 247-51 (1976).
Advanced Organic Chemistry, F. A. Carey and R. J. Sundberg, Plenum Press, p. 145 (1977).
Walsh, P.S., Nucleic Acids Research, vol. 20, No. 19 5061-5065 (1992).
L.J. Kricka, G.H. Thorpe In Luminescence Immunoassays and Molecular Applications, CRC Press, Boca Raton, 1990, pp. 77-98.
T. Candy, P. Jones, J. Biolumin. Chemilumin. vol. 6, 239-43 (1991).

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