Aryl-isoxazolo-4-yl-oxadiazole derivatives

Details Aryl-isoxazolo-4-yl-oxadiazole derivatives Aryl-isoxazolo-4-yl-oxadiazole derivatives

2006-12-15

2009-06-02

Shiao, Rei-Tsang (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S378000, C548S143000, C548S247000

Reexamination Certificate

active

07541372

ABSTRACT:
The present invention is concerned with isoxazol-4-yl-oxadiazole derivatives of formulawhereinR1,R2, andR3, are as defined in the specification and pharmaceutically acceptable acid addition salts thereof.This class of compounds has high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.

REFERENCES:
patent: 2003/0055085 (2003-03-01), Wagener et al.
patent: 2004/0006226 (2004-01-01), Ladduwahetty et al.
patent: 2007/0060589 (2007-03-01), Purandare et al.
patent: 2336589 (1999-10-01), None
patent: WO 01/29015 (2001-04-01), None
patent: WO 02/50062 (2002-06-01), None
patent: WO 02/081474 (2002-10-01), None
patent: WO 03/004027 (2003-01-01), None
patent: WO 2005/123672 (2005-12-01), None
patent: WO 2006/0044617 (2006-04-01), None
patent: WO 2006/0069155 (2006-06-01), None
Gaba A receptor, Wikipedia.
Sur et al. Brain Research, vol. 822 (1999), p. 265-270.
Otani et al., Neuroscience Letters vol. 381 (2005), p. 108-113.
McNamara et al., Psychobiology (1993), vol. 21, pp. 101-108.
Lam et al., Bioorganic & Medicinal Chemistry Letters (2003) vol. 13(10) pp. 1795-1799.
Wang et al., Journal of Fluorine Chemistry, vol. 111(2) pp. 241-246 (2001).
Roy et al., Synthesis, 2003 pp. 1347-1356.
White, et al., Journal of Organic Chemistry (1981), vol. 46(11) pp. 2273-2280.
Shi Shun et al., J. Org. Chem. vol. 68 (2003) pp. 6810-6813.
Burke, et al., Journal of Natural Products, 1986, vol. 49, pp. 522-523.
Hamper et al., J. Agric. Food Chem. (1995), vol. 43, pp. 219-228.
Kumar, et al., Tetrahedron Letters, vol. 47, (2006), p. 1457-1460.
Hormi, Organic Syntheses, vol. 8, p. 247 (1993) & vol. 66, (1988), p. 173.
Andosova et al., Pharmaceutical Chemistry Journal (English Translation), vol. 12, No. 8, 1978, pp. 1019-1022.
Doyle, et al., Journal of the Chem. Society, 1963, pp. 5838-5845.
Anderson, et al., Journal of Organic Chem. vol. 51(6), 1986, pp. 945-947.
Bourbeau et al., Organic Letters, vol. 8(17),2006, pp. 3679-3680.

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