Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-10-04
2008-05-27
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S248000
Reexamination Certificate
active
07378435
ABSTRACT:
The present invention is concerned with aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives of formula IwhereinR1, R2, R3, R4, and R5are as defined in the specification and claims and with their pharmaceutically acceptable acid addition salts. The invention also relates to methods for preparing such compounds. This class of compounds has a high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease. Thus, the invention also is concerned with pharmaceutical compositions containing compounds of formula I or their pharmaceutically acceptable acid addition salts and methods for the treatment of GABA Aα5 mediated diseases, including Alzheimer's disease.
REFERENCES:
patent: WO 01/29015 (2001-04-01), None
patent: WO 02/50062 (2002-06-01), None
patent: WO 02/814784 (2002-10-01), None
patent: WO 03/004027 (2003-01-01), None
patent: WO 2005/123672 (2005-12-01), None
McNamara et al., Psychobiology (1993), vol. 21(2) pp. 101-108.
Hamper et al., J. Agric. Food Chem. (1995), vol. 43, pp. 219-228.
Buettelmann Bernd
Han Bo
Knust Henner
Nettekoven Matthias
Thomas Andrew
Hoffmann-La Roche Inc.
Johnston George W.
Prior Kimberly J.
Rocha-Tramaloni Patricia S.
Saeed Kamal A.
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