Aryl imidazole compounds having phosphodiesterase IV inhibitory

Details Aryl imidazole compounds having phosphodiesterase IV inhibitory Aryl imidazole compounds having phosphodiesterase IV inhibitory

1999-04-12

2000-08-15

Stockton, Laura L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514396, 514398, 5483345, 5483381, 5483315, 5483431, 5483425, 5483435, 5483461, A61K 314164, C07D23364, C07D23390

Patent

active

061037494

ABSTRACT:
Novel compounds which are effective PDE IV inhibitors are disclosed. These compounds have the general structure of: ##STR1## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, X.sub.1, X.sub.2 and Z are described herein. The compounds possess improved PDE IV inhibition as compared to rolipram as well as with improved selectivity with regard to PDE III inhibition. Pharmaceutical compositions containing the same and methods of treatment are also disclosed.

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