Aryl imidate activated polyalkylene oxides

Details Aryl imidate activated polyalkylene oxides Aryl imidate activated polyalkylene oxides

1992-12-22

1994-03-29

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Imidate esters

C07C24900

Patent

active

052986438

ABSTRACT:
Water-soluble aryl imidate activated polyalkylene oxides having improved hydrolytic stability and conjugates of the aryl imidate activated polyalkylene oxides with biologically active nucleophiles are disclosed. Methods of preparing the activated polyalkylene oxides and conjugates thereof are also disclosed.

REFERENCES:
patent: 4492657 (1985-01-01), Heiss
patent: 4791192 (1988-12-01), Nakagawa et al.
patent: 5109120 (1992-04-01), Ueno et al.
Hunter et al., J. Amer. Chem. Soc., 84, 3491-504 (1962).
Brown et al., Biochem. and Biophys. Res. Comm., 67(1), 126-32 (1975).

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