Aryl fused substituted 4-oxy-pyridines

Details Aryl fused substituted 4-oxy-pyridines Aryl fused substituted 4-oxy-pyridines

2008-05-13

2008-05-13

Andres, Janet L. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S301000, C514S302000, C544S236000, C546S114000, C546S116000

Reexamination Certificate

active

11003195

ABSTRACT:
Disclosed are compounds of the formula:wherein X, Q, W andare as defined herein. These compounds are agonists, antagonists or inverse agonists for GABAAbrain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAAbrain receptors and are therefore useful in the diagnosis and treatment of anxiety, depression, Down Syndrome, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Compounds of the invention are also useful as probes for the localization of GABAAreceptors in tissue samples.

REFERENCES:
patent: 6828329 (2004-12-01), Cai et al.
Krogsgaard-Larsen et. al., “GABA Receptor Agonists, Partial Agonists, Antagonists. Design and Therapeutic Prospects”, Journal of Medicinal Chemistry, vol. 37, No. 16, Aug. 5, 1994.
Quintela, et. al., “Synthesis and antihistaminic activity of 2-guanidino-3-cyanopyridines and pyrido [2,3-d]pyrimidines”, Bioorganic & Medicinal Chemistry (1997), 5 (8), pp. 1543-1553.
Krogsgaard-Larsen et. al., “GABA Receptor Agonists, Partial Agonists, and Antagonists. Design and Therapeutic Prospects”, Journal of Medicinal Chemistry, vol. 37, No. 16, Aug. 5, 1994.

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