Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands

Details Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands

2006-05-02

2006-05-02

Davis, Zinna Northington (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S122000, C546S123000

Reexamination Certificate

active

07037922

ABSTRACT:
Disclosed are compounds of formula (I) or pharmaceutically acceptable non-toxic salts or pharmaceutically acceptable solvates thereof wherein: (II) represents (a), (b), (c) or (d) and W, X, Y, A, B, C, D, E are variables as described herein. These compounds are highly selective agonists or antagonists at NK3 receptors or prodrugs thereof. The novel tachykinin NK-3 receptor antagonists contained in this invention have potential utility in the treatment of a broad array of disorders and diseases of the central nervous system (CNS) and periphery in mammals in which activation of NK-3 receptors is of importance.

REFERENCES:
patent: 5811553 (1998-09-01), Farina et al.
patent: 6277862 (2001-08-01), Giardina et al.
patent: 6355654 (2002-03-01), Giardina et al.
patent: 6432977 (2002-08-01), Giardina et al.
patent: 6608083 (2003-08-01), Farina et al.
patent: 6613770 (2003-09-01), Farina et al.
patent: 6743804 (2004-06-01), Giardina et al.
patent: 6780875 (2004-08-01), Farina et al.
patent: 829894 (1952-01-01), None
patent: WO 97/19926 (1997-06-01), None
patent: 00/31037 (2000-06-01), None
patent: 02/38547 (2002-05-01), None
patent: 02/38548 (2002-05-01), None
patent: 02/43734 (2002-06-01), None
patent: 02/44154 (2002-06-01), None
Gao et al, Current Medicinal Chemistry, 1999, 6: 375-388.
Giardina, et al., (1999)IL FARMACO,54:364-374.

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