Aryl furan derivatives as PDE IV inhibitors

Details Aryl furan derivatives as PDE IV inhibitors Aryl furan derivatives as PDE IV inhibitors

1998-09-28

2000-02-01

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514262, 514336, 514367, 514375, 514397, 514461, 544265, 5462834, 548170, 548222, 5483157, 549497, 549499, 549502, A61K 31505, A61K 3134, C07D40100, C07D27762

Patent

active

060203390

ABSTRACT:
The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). ##STR1## The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula I.

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