Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2008-04-29
2008-04-29
Safed, Kamal A. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C562S493000, C514S365000, C514S570000, C514S568000, C548S202000
Reexamination Certificate
active
10565557
ABSTRACT:
The present invention is related to aryl dicarboxamides of formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholes-terolemia, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of aryl dicarboxamides of formula (I) to modulate, notably to inhibit the activity of PTPs. A is an aminocarbonyl moiety; Cy is an aryl, heteroaryl, aryl-heteroaryl, heteroaryl-aryl, aryl-aryl, cycloalkyl or heterocycle group; n is either 0 or 1; R1and R2are independently from each other is selected from the group consisting of hydrogen or C1-C6-alkyl; R4and R5are each independently from each other selected from the group consisting of H, hydroxy, C1-C6alkyl, carboxy, C1-C6alkoxy, C1-C3alkyl carboxy, C2-C3alkenyl carboxy, C2-C3alkynyl carboxy, amino or R4and R5may form an unsaturated or saturated heterocyclic ring, whereby at least one of R4or R5is not a hydrogen or C1-C6alkyl
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Bombrun Agnes
Pons Jean-Francois
Swinnen Dominique
Thomas Russel J.
Laboratoires Serono SA
Loewe Sun Jae Y
Safed Kamal A.
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