Aryl-cycloalkyl-alkanolamines for treatment of neurotoxic injury

Details Aryl-cycloalkyl-alkanolamines for treatment of neurotoxic injury Aryl-cycloalkyl-alkanolamines for treatment of neurotoxic injury

1987-10-23

1990-07-31

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514319, 514408, A61K 3140, A61K 31445

Patent

active

049450972

ABSTRACT:
Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows such conditions as stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of an aryl-cycloalkyl-alkanolamine compound as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites.

REFERENCES:
S. M. Rothman and J. W. Olney, Annals of Neurology, vol. 19, No. 2 (1986).
Anis, N. A. et al., Br. J. Pharmacol., 79, 565, (1983).
J. W. Olney et al., Neuroscience Letters, 68, 29-34 (1986).
S. D. Berry et al., Eur. J. Pharm., 96, 261-267, (1983).
M. E. Goldman et al., FEBS Lett., 170, 333-336 (1985).
W. Maragos et al., Eur. J. Pharmacol., 123, 173-174 (1986).
R. Quirion, Proc. Nat'l. Acad. Sci. U.S.A., 78, 5881 (1981).
L. D. Snell et al., J. Pharmacol. Exp. Ther., 235, 50-56 (1985).
E. H. F. Wong et al., Proc. Nat'l. Acad. Sci. U.S.A., vol. 83, pp. 7104-7108 (Sep. 1986).
L. S. Goodman et al., The Pharmacological Basis of Therapeutics, 7th Edn., pp. 483-485, Macmillan (1975).
W. W. Fleishhaker et al., J. Affective Disorder, 12(2), 153-157 (1987).
E. K. G. Syvalahti et al., Pharmacol. Toxicol. (Copenhagen), 60(1), 66-69 (1987).
M. Das et al., Toxicol. Appl. Pharmacol., 39(1), 149-152 (1977).
N. Mann et al., Arch. Pharm. (Weinheim, Ger., 309(4), 320-325, (1976).
C. Schroeder et al., Antiviral Res., Suppl. 1, 95-99 (1985).
A. Hitri et al., Psychopharmacol. Bull., 23 (1) 33-37 (1987).
J. P. McEvoy et al., Psychoparmacol. Bull., 23(1) 30-32 (1987).

Affiliated with

Also associated with

Rating

Aryl-cycloalkyl-alkanolamines for treatment of neurotoxic injury does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aryl-cycloalkyl-alkanolamines for treatment of neurotoxic injury, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aryl-cycloalkyl-alkanolamines for treatment of neurotoxic injury will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1398952