Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-05-08
1991-04-30
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142358, 514255, 514315, 514307, 514609, 544 59, 544106, 544388, 546153, 546189, 558419, 564230, C07D29512, C07C25500, C07C23900
Patent
active
050118374
ABSTRACT:
Novel compounds of the formula ##STR1## and tautomers thereof, wherein at least one of R.sub.2, R.sub.3 and R.sub.4 is a strong electron withdrawing group, are disclosed. These compounds possess potassium channel activating activity and, as such, are useful as antihypertensive agents. Advantageously, the compounds of the present invention have shown less cardiac effects than known potassium channel activators.
Also disclosed is a process for preparing these and other compounds.
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S. D. Longman et al., Pharmacology, vol. 110, 1989, p. 45 (110:530n).
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Atwal Karnail
Grover Gary J.
McCullough John R.
E. R. Squibb & Sons Inc.
Furman Jr. Theodore R.
Shah Mukund J.
Ward Edward C.
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