Aryl coupling process

Details Aryl coupling process Aryl coupling process

1983-08-15

1985-10-01

Chan, Nicky

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260465D, 260465F, 560 21, 560 59, 560 81, C07C12166, C07C 69616

Patent

active

045445095

ABSTRACT:
An arylamine is coupled with an aromatic compound in the presence of water, an inorganic nitrite, and an alkanoic acid containing 5-7 carbons. In a preferred embodiment of the invention, 2-(4-amino-3-fluorobenzene)propionitrile is coupled with benzene in the presence of water, sodium nitrite, and hexanoic acid to form a flurbiprofen intermediate.

REFERENCES:
patent: 4266069 (1981-05-01), Walker

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