Aryl-containing 5-acylindolinones, the preparation thereof...

Details Aryl-containing 5-acylindolinones, the preparation thereof... Aryl-containing 5-acylindolinones, the preparation thereof...

2007-02-13

2007-02-13

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S486000

Reexamination Certificate

active

11077259

ABSTRACT:
The present invention relates to aryl-containing 5-acylindolinones of general formulawherein R1to R3are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).

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H.N. Bramson, et al. “Oxinide-Based Inhibitors of Cyclin-Dependent Kinase 2 (CDK2): Design, Synthesis, Enzymatic Activities, and X-ray Crystallographic Analysis”, J. med. Chem. 2001 vol. 44, pp. 4339-4358 : XP-002274118.

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