Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-07-03
2007-07-03
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S252110, C514S252150, C514S253010, C514S255030, C544S238000, C544S295000, C544S357000, C544S360000, C544S393000
Reexamination Certificate
active
10467932
ABSTRACT:
The present invention relates to novel compounds, the preparation and use, particularly therapeutic, thereof. More specifically, it relates to compounds derived from aryl carbamates, the preparation and use thereof, particularly in the field of human and animal health. The compounds according to the invention are preferably 5-HT4serotoninergic receptor ligands and can therefore be used in the therapeutic or prophylactic treatment of any disorder involving a 5-HT4receptor. The invention also relates to pharmaceutical compositions comprising such compounds, the preparation and use thereof and treatment methods using said compounds. Compounds according to the invention include compounds of the following formula (I):
REFERENCES:
patent: 5246935 (1993-09-01), Jeppesen et al.
patent: 5605896 (1997-02-01), Leonardi et al.
patent: 0 199 400 (1986-10-01), None
patent: 0 625 507 (1994-11-01), None
patent: 0 665 216 (1995-08-01), None
patent: 0 903 349 (1999-03-01), None
patent: 0 972 773 (2000-01-01), None
patent: 2 387 955 (1978-11-01), None
patent: WO 93/03725 (1993-03-01), None
patent: WO 93/10742 (1993-06-01), None
patent: WO 93/20071 (1993-10-01), None
patent: WO 95/25100 (1995-09-01), None
patent: WO 95/31449 (1995-11-01), None
patent: WO 99/25687 (1999-05-01), None
patent: WO 00/21926 (2000-04-01), None
patent: WO 00/29377 (2000-05-01), None
patent: WO 00/31032 (2000-06-01), None
patent: WO 00/35449 (2000-06-01), None
patent: WO 00/43391 (2000-07-01), None
patent: WO 01/25199 (2001-04-01), None
Robichaud et al. in Annual Reports in Medicinal Chemistry, vol. 36, p. 11-20 (2000).
Database Chemabs, Curtet et al, “Solid-phase synthesis of 2-methoxyaniline derivatives by the traceless silicon linker strategy”, & Tetrahedron Lett., 1999, 40(49), 8563-8566.
Database Chemabs, Soulier et al, “Arylcarbamate Derivatives of 1-Piperidineethanol as Potent Ligands for 5-HT4 Receptors”, & J. Med. Chem, 1997, 40(11), 1755-1761.
Database Chemabs, Sedlarova et al, “Studies of physicochemical properties of compounds from the group of 1-(4-phenyl-1-piperazinyl)-3-methoxy-2-propyl 2- and 3-alkoxyphenylcarbamate esters” & Ceska Slov. Farm, 1999, 48(4), 170-174.
Database Chemabs, Hrobonova et al, “Study of local anesthetics. Part 146. Correlation between local anethesia, coded structural information, and chromatographic properties for homologous series of alkoxysubstituted esters of phenylcarbamic acid using a neutral network” & PHARMAZIE, 1999, 54(1), 44-47.
Database Chemabs, Huang et al, “Synthesis and Quantitative Structure-Activity Relationships of N-(1-Benzylpiperidin-4-yl) phenylacetamides and Related Analogs as Potent and Selective .sigma.1 Receptor Ligands” & J. Med. Chem., 1998, 41(13), 2361-2370.
Database Chemabs, Soulier et al, “Arylcarbamate Derivatives of 1-Piperdineethanol as Potent Ligands for 5-HT4 Receptors” & J. Med. Chem., 1997, 40(11), 1755-1761.
Database Chemabs, Cernuskova et al, “3-(4-Phenyl-1-piperazinyl)-2-hydroxy-1-propyl esters of alkoxyphenylcarbamic acids and methods for their preparation” & Farmaceuticka Fakulta UK, Slovakia, Apr. 3, 1996.
Database Chemabs, Cernuskova et al, “3-[4- (2-Methoxyphenyl) -1-piperazinyl] -2-hydroxy-1-propyl esters of alkoxyphenylcarbamic acids and method for their preparation” & Farmaceuticka Fakulta UK, Slovakia, Apr. 3, 1996.
Database Chemabs, Pokorna et al, “Local anesthetics, CXIX. Preparation physicochemical properties and local anesthetic effectiveness of 1,4-bis [2- (2-, 3-, 4-alkoxyphenylcarbamoyloxy) ethyl] -piperazinium dichlorides” & Ceska Slov. Farm, 1996, 45(4), 213-217.
Database Chemabs, Seginko et al, “Ca-antagonistic activity of some 1,4-piperazine derivatives” & PHARMAZIE, 1995, 50(5), 368-9.
DatabaseChemabs, Buciova et al, “Studies of local anesthetics. Part 114. Preparation, local anesthetic and antiarrhythmic effectiveness of 1-(4-methyl-1-piperazinyl)-3-methoxy-2-propyl esters of 2-, 3- and 4- alkoxyphenylcarbamic acids” & Cesk. Farm, 1993, 42(5), 235-8.
Database Chemabs, Sedlarova et al, “Correlation between log k, RM, C and infiltration anesthesia (U) in the group of 4-alkylpiperazinoethyl esters of 2- heptyloxyphenylcarbamic acid” & Cesk. Farm, 1993, 42(2), 92-4.
Database Chemabs, Stankovicova et al, “Study of the relation between physiol-chemical properties and the biological activity of basic heptacaine analogs”, PHARMAZIE, 1992, 47(11), 874-5.
Database Chemabs, Do Ngoc Minh et al, “Study of local anesthetics. Part 98. Preparation and local anesthetic activity of 4-alkylpiperazinoethyl esters of o-heptyloxyphenylcarbamic acid” & PHARMAZIE, 1992, 47(2), 94-6.
Database Chemabs, Stankovicova et al, “Kinetics of the alkaline hydrolysis of basic analogs of heptacaine hydrochloride” & PHARMAZIE, 1991, 46(4), 294-5.
Database Chemabs, Stankovicova et al, “Kinetics of alkaline hydrolysis of hepatacaine chloride basic analogs” & Chem Pap., 1990, 44(2), 171-6.
Database Chemabs, Csollei et al, “Studies of local anesthetics. LXXXV. N-Alkyl-4-piperidyl esters of o- and m-alkoxycarbanilic acids with local anesthetic and antiarrhythmic effects”, & Cesk. Farm, 1986, 35(7), 299-302.
Database Chemabs, Dubey et al, “Derivatives of N-aryl-N-aminopiperazines as potential cardiovascular agents” & Pol. J. Pharmacol. Pharm, 1981, 33(3), 349-57.
Database Chemabs, Ahmad et al, “Piperazinylthioureas and thiozolidones as anthelminitcs” & Proc. Natl. Acad. Sci., India, Sect. A, 1980, 50(3), 163-8.
Database Chemabs, Csollei, “N-butyl-3-pyrrolidinyl- and N-ethyl-2-pyrrolidinylmethyl esters of alkoxycarbanilic acids with local anesthetic effects” & Farm. Obz, 1981, 50(8), 407-11.
Database Chemabs, Chaturvedi et al, Anticonvulsant activity of N,N′-bis[3-(3-substituted ures) propy] piperazines J. Pharm. Sci, 1975, 64(3), 454-6.
Database Chemabs, Chaturvedi et al, “Piperazinothioureas as anticonvulsants” & Curr. Sci., 1972, 41(7), 253-4.
Database Chemabs, Mager et al, “Multivariate Free-Wilson analysis” & PHARMAZIE, 1981, 36(6), 427-9.
Database Chemabs, Gupta et al, “Synthesis of substituted piperidino carbamaides. Correlation between CNS [central nervous system] effects and selective inhibition of NAD-dependent oxidations” & J. Pharm. Sci., 1974, 63(8), 1227-30.
Curtet Sophie
Fischmeister Rodolphe
Langlois Michel
Launay Michele
Lezoualc'h Frank
Bernhardt Emily
Centre National de la Recherche Scientifique
Cerep
Institut National de la Santa et de la Recherche Medicale (inser
Nixon & Vanderhye P.C.
LandOfFree
Aryl carbamate derivatives, preparation and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aryl carbamate derivatives, preparation and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aryl carbamate derivatives, preparation and use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3821647