Aryl boronic acids for treating obesity

Details Aryl boronic acids for treating obesity Aryl boronic acids for treating obesity

2005-02-22

2005-02-22

Nazario-Gonzalez, Porfirio (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Boron containing doai

C558S044000, C562S007000

Reexamination Certificate

active

06858592

ABSTRACT:
Disclosed is a phenyl boronic acid compound represented by Structural Formula (I):Ar is a substituted or unsubstituted aryl group.Z and Z′ are independently —O—. —NH— or —S—.X is an electron withdrawing group.R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups and Y is —H, an amine, —[NH—(CH2)q]r—NH2, halogen, —CF3, thiol ammonium, alcohol, —COOH, —SO3H, —OSO3H or phosphonium group covalently bonded to the terminal position of R. Each —NH— in —[NH—(CH2)q]r—NH2is optionally N-alkylated or N,N-dialkylated and —NH2in —[NH—(CH2)q]r—NH2is optionally N-alkylated, N,N-dialkylated or N,N,N-trialkylated.q is an integer from 2 to about 10 and r is an integer from 1 to about 5.R1and R1′are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or, taken together, are a C2-C5 substituted or unsubstituted alkylene group optionally comprising an amine linking group [—N+(R1a)—]. Each R1is Structural Formula (I) is preferably —H.R1ais —H, alkyl, substituted alkyl, phenyl or substituted phenyl.Also disclosed is a method of treating obesity in a subject by administering an effective amount of a compound represented by Structural Formula (I) and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier or diluent.

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