Aryl boronate functionalized polymers for treating obesity

Details Aryl boronate functionalized polymers for treating obesity Aryl boronate functionalized polymers for treating obesity

2006-05-09

2006-05-09

Zimmer, Marc S. (Department: 1712)

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

C424S078180, C424S078260, C525S337000, C528S004000, C528S008000, C528S394000

Reexamination Certificate

active

07041280

ABSTRACT:
Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups. The phenyl boronate ester, boronamide and boronate thioester groups are represented by one of the following structural formulas:Ar in Structural Formulas (I) and (II) is substituted or unsubstituted; and each Z is —O—, —NH— or —S— and is independently selected. Pharmaceutically acceptable salts of the polymer are also included. The aryl boronate ester, boronamide or boronate thioester can be cleaved to release the corresponding aryl boronic acid.Also disclosed are pharmaceutical compositions comprising the polymers of the present invention and a pharmaceutically acceptable carrier or diluent; and methods of treating a subject for obesity with the polymers of the present invention.

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