Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-12-04
2000-10-03
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514274, 544310, 544316, A61K 31505, C07D23952
Patent
active
061273767
ABSTRACT:
This invention is directed to aryl and heterocyclyl substituted pyrimidine derivatives selected from the following formulae: ##STR1## wherein Z.sup.1, Z.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein. These compounds are useful as anti-coagulants.
REFERENCES:
patent: 4064169 (1977-12-01), Hamano et al.
patent: 5332822 (1994-07-01), Misra
patent: 5451700 (1995-09-01), Morrissey et al.
patent: 5612363 (1997-03-01), Mohan et al.
patent: 5633381 (1997-05-01), Dallas et al.
patent: 5691364 (1997-11-01), Buckman et al.
patent: 5693641 (1997-12-01), Buckman et al.
patent: 5726173 (1998-03-01), Mohan et al.
patent: 5726198 (1998-03-01), Mohan et al.
patent: 5728697 (1998-03-01), Mohan et al.
patent: 5731308 (1998-03-01), Mohan et al.
patent: 5731311 (1998-03-01), Mohan et al.
patent: 5753635 (1998-05-01), Buckman et al.
patent: 5846970 (1998-12-01), Buckman et al.
patent: 5846972 (1998-12-01), Buckman et al.
patent: 5849759 (1998-12-01), Arnaiz et al.
patent: 5859005 (1999-01-01), Mohan et al.
patent: 5863914 (1999-01-01), Mohan et al.
patent: 5877181 (1999-03-01), Buckman et al.
patent: 5883100 (1999-03-01), Buckman et al.
patent: 5889005 (1999-03-01), Buckman et al.
Delia, T. et al. Ring-based analogs of pentamidine . . . Bioorg. Med. Chem. Lett. 6 2367-2369, 1996.
Tidwell, R. et al., "Strategies for Anticoagulation with Synthetic Protease Inhibitors, Xa Inhibitors Versus Thrombin Inhibitors," Thrombosis Research, (1980) 19:339-349.
Wagner, G. et al., "Synthese von a-a'-Bis[amidinobenzyliden]-und a-a' Bis-[amidinobenzyl]-cycloalkanonen," Pharmazie, (1977) 32, 141-145.
Sturzebecher, J. et al., "Cyclic Amides of N.alpha.-arysulfonylaminoacylated 4-amidinophenylalanine--Tight Binding Inhibitors of Thrombin," Thrombosis Research, (1983) 29:635-642.
Kikumoto, R. et al., "Selective inhibition of Thrombin by (2R,4R)-4-Methyl-1-[N.sup.2 -[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)-sulfonyl]-L-arginyl)]-2piperi dinecarboxylic Acid," Biochemistry, (1984) 23:85-90.
Sturzebecher, J. et al., "Synthetic Inhibitors of Serine Proteinases XXIII, Inhibition of Factor Xa by Diamidines", Thrombosis Research, (1980) 17:545:548.
Chauhan, P. et al., "Effect of new diamidines against Leishmania donovani infection," Indian Journal of Experimental Biology, (1993) 31:196-198.
Ashley, J. et al., "The Search for Chemotherapeutic Amidines. Part XVI. Amidinoanilino-1,3,5-triazines and Related Compounds", J. of the Chemical Society, (1960) 4525:4532.
Geratz, J. et al., "The Inhibition of Urokinase by Aromatic Diamidines" Thrombos. Diathes haemorrh. (Stuttg.), (1975)33:230-243.
Geratz, J. et al., "Novel Bis (benzamidino) Compounds with an Aromatic Central Link. Inhibitors of Thrombin, Pancreatic Kallikrein, Trypsin, and Complement" J. of Medicinal Chemistry, (1976) 19(5):634-639.
Chauhan, P. et al., "Antiparasitic Agents: Part VI--Synthesis of 1,2-,1,3-& 1,4-Bis(4-substituted aryloxy)benzenes & Their Biological Activities", Indian Journal of Chemistry, (1988) 27B:38-42.
U.S. patent application No. 09/196,921, filed Nov. 19, 1998, entitled: Polyhydroxylated Monocyclic N-Heterocyclic Derivatives as Anti-Coagulants.
U.S. patent application No. 09/187,459, filed Nov. 5, 1998, entitled: Ortho-Anthranilamide Derivatives as Anti-Coagulants.
Davey David D.
Phillips Gary B.
Balasubramanian V
Berlex Laboratories Inc.
Raymond Richard L.
Roth Carol J.
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