Aryl and heteroaryl(phosphinylmethyl)phosphonate squalene synthe

Details Aryl and heteroaryl(phosphinylmethyl)phosphonate squalene synthe Aryl and heteroaryl(phosphinylmethyl)phosphonate squalene synthe

1993-10-18

1994-12-20

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 89, 514 99, 514107, 549 6, 549218, 546 22, 548413, 558155, 558156, 562 21, A61K 3167, A61K 31665, C07D33300, C07F 906

Patent

active

053746287

ABSTRACT:
Phosphonic acid squalene synthetase inhibitors are provided which are effective in lowering serum cholesterol and have the formula ##STR1## wherein m is 0 to 3, n is 1 to 5, Y.sup.1 and Y.sup.2 are H or halogen, R.sup.2, R.sup.3 and R.sup.4 are H, metal ion, C.sub.1 to C.sub.8 alkyl, C.sub.3 to C.sub.12 alkenyl, or prodrug ester, and R.sup.1 is a substituted or unsubstituted heteroaryl group or a substituted phenyl group.

REFERENCES:
patent: 4871721 (1989-10-01), Biller

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