Aryl and heteroaryl compounds, compositions, and methods of use

Details Aryl and heteroaryl compounds, compositions, and methods of use Aryl and heteroaryl compounds, compositions, and methods of use

2007-04-24

2007-04-24

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

11069521

ABSTRACT:
This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be useful as antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be used to inhibit the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway utilizing factor IX and/or XI.

REFERENCES:
patent: 4675439 (1987-06-01), Mita et al.
patent: 4717736 (1988-01-01), Rokach et al.
patent: 5273990 (1993-12-01), De Lombert et al.
patent: 5354905 (1994-10-01), Sato et al.
patent: 5397798 (1995-03-01), Fitch et al.
patent: 5514719 (1996-05-01), LaTorse et al.
patent: 5518735 (1996-05-01), Sturzebecher et al.
patent: 5679671 (1997-10-01), Oinuma et al.
patent: 5703106 (1997-12-01), Fruh et al.
patent: 5750520 (1998-05-01), Danilewicz et al.
patent: 5780498 (1998-07-01), Saika et al.
patent: 5908843 (1999-06-01), Gante et al.
patent: 5977075 (1999-11-01), Ksander et al.
patent: 5977178 (1999-11-01), Hansen et al.
patent: 6001820 (1999-12-01), Hirsh et al.
patent: 6087380 (2000-07-01), Hauel et al.
patent: 6127341 (2000-10-01), Hansen et al.
patent: 6191171 (2001-02-01), DeLaszlo et al.
patent: 6194448 (2001-02-01), Bredrget et al.
patent: 6194458 (2001-02-01), Baker et al.
patent: 6262084 (2001-07-01), Biediger et al.
patent: 6284871 (2001-09-01), Mertens et al.
patent: 6291511 (2001-09-01), Durette et al.
patent: 6300330 (2001-10-01), Stocker et al.
patent: 6306840 (2001-10-01), Adams et al.
patent: 6331564 (2001-12-01), Brugnara et al.
patent: 6342504 (2002-01-01), Brunk et al.
patent: 6358978 (2002-03-01), Ritzeler et al.
patent: 6362204 (2002-03-01), Head et al.
patent: 6388138 (2002-05-01), Lee et al.
patent: 6388148 (2002-05-01), Heilmann et al.
patent: 6403584 (2002-06-01), De Laszlo et al.
patent: 6420396 (2002-07-01), Albers et al.
patent: 6423727 (2002-07-01), De Lombaert et al.
patent: 6469047 (2002-10-01), Jackson et al.
patent: 6521666 (2003-02-01), Sircar et al.
patent: 6528275 (2003-03-01), Quibell et al.
patent: 6528655 (2003-03-01), N'Zemba et al.
patent: 6559174 (2003-05-01), Lin et al.
patent: 6743790 (2004-06-01), Klingler et al.
patent: 7122580 (2006-10-01), Mjalli et al.
patent: 2002/0016461 (2002-02-01), Albers et al.
patent: 2002/0095041 (2002-07-01), Chan et al.
patent: 2002/0103192 (2002-08-01), Curtin et al.
patent: 2002/0151595 (2002-10-01), Ries et al.
patent: 2002/0173656 (2002-11-01), Peyman et al.
patent: 2002/0198195 (2002-12-01), Nazare et al.
patent: 2003/0045480 (2003-03-01), Safar et al.
patent: 2003/0149083 (2003-08-01), Tanaka et al.
patent: 2004/0106626 (2004-06-01), South et al.
patent: 2004/0126856 (2004-07-01), Bajaj et al.
patent: 2004/0152888 (2004-08-01), Bourguignon et al.
patent: 2004/0198780 (2004-10-01), Liu et al.
patent: 2004/0220180 (2004-11-01), Glick et al.
patent: 2004/0241781 (2004-12-01), Glick et al.
patent: 2005/0049310 (2005-03-01), Mjalli et al.
patent: 2005/0053600 (2005-03-01), Lane
patent: 2005/0059705 (2005-03-01), Mjalli et al.
patent: 2005/0059713 (2005-03-01), Mjalli et al.
patent: 2005/0065346 (2005-03-01), Ries et al.
patent: 2005/0165107 (2005-07-01), Inoue et al.
patent: 2005/0187390 (2005-08-01), Schmitz et al.
patent: 2005/0187409 (2005-08-01), Powers et al.
patent: 2005/0203135 (2005-09-01), Burdick et al.
patent: 2005/0256116 (2005-11-01), Clary et al.
patent: 199 28 424 (2000-12-01), None
patent: 0 150 118 (1987-09-01), None
patent: 1 213 288 (2002-12-01), None
patent: 2 847 251 (2004-05-01), None
patent: 1 501 541 (1978-02-01), None
patent: 2 354 440 (2001-03-01), None
patent: 61-227555 (1986-10-01), None
patent: 09-124569 (1997-05-01), None
patent: 2001-089368 (2001-04-01), None
patent: 2003-321358 (2003-11-01), None
patent: 2004-323487 (2004-11-01), None
patent: WO 1995-12611 (1995-05-01), None
patent: WO 1996-33170 (1996-10-01), None
patent: WO 1997-23508 (1997-07-01), None
patent: WO 1997-40065 (1997-10-01), None
patent: WO 1997-42216 (1997-11-01), None
patent: WO 1998-37075 (1998-08-01), None
patent: WO 1998-53817 (1998-12-01), None
patent: WO 1998-58950 (1998-12-01), None
patent: WO 1999-26923 (1999-06-01), None
patent: WO 1999-36393 (1999-07-01), None
patent: WO 2000-35864 (2000-06-01), None
patent: WO 2000-37429 (2000-06-01), None
patent: WO 2000-67746 (2000-11-01), None
patent: WO 2000-68188 (2000-11-01), None
patent: WO-2000-76971 (2000-12-01), None
patent: WO 2001-10823 (2001-02-01), None
patent: WO 2001-21584 (2001-03-01), None
patent: WO 2001-38309 (2001-05-01), None
patent: WO 2001-056994 (2001-08-01), None
patent: WO 2001-68586 (2001-09-01), None
patent: WO 2002-18320 (2002-03-01), None
patent: WO 2002-26717 (2002-04-01), None
patent: WO 2002-062748 (2002-08-01), None
patent: WO 2002-083842 (2002-10-01), None
patent: WO 2002-085841 (2002-10-01), None
patent: WO 2003-002545 (2003-01-01), None
patent: WO 2003-006444 (2003-01-01), None
patent: WO 2003-007945 (2003-01-01), None
patent: WO 2003-033496 (2003-04-01), None
patent: WO 2003-072536 (2003-09-01), None
patent: WO 2004-014844 (2004-02-01), None
patent: WO 2004-046091 (2004-06-01), None
patent: WO 2004-080970 (2004-09-01), None
patent: WO 2004-084842 (2004-10-01), None
patent: WO 2004-110983 (2004-12-01), None
patent: WO 2005-012288 (2005-02-01), None
patent: WO 2005-039494 (2005-05-01), None
Alves et al., “A Novel 3-step Enantioselective Synthesis of Pyrenylalanine with Subsequent Incorporation Into Opioid, CCK and Melanotropin Ligands” Biochemical and Biophysical Research Communications, vol. 318, pp. 335-340, (2004).
Amino et al., “Phenylalanine Derivatives Enhancing Intestinal Absorption of Insulin in Mice” Chemical and Pharmaceutical Bulletin, vol. 36, pp. 4426-4434, (1988).
Ankersen et al., “Demonstration of the Strength of Focused Combinatorial Libraries in SAR Optimisation of Growth Hormone Secretagogues” European Journal of Medicinal Chemistry, vol. 34, pp. 783-790, (1999).
Au-Yeung et al., “Unnatural A-Amino Acids Via Asymmetric Hydrogenation of Enamides” Transition Metals for Organic Synthesis and Fine Chemicals, vol. 2, pp. 14-25, (1998).
Balwierczak et al., “Characterization of a Potent and Selective Endothelin-B Receptor Antagonist, IRL 2500” Journal of Cardiovascular Pharmacology, vol. 26, pp. S393-S396, (1995).
Batt et al., “5-Amidinoindoles as Dual Inhibitors of Coagulation Factors IXa and Xa” Bioorganic & Medicinal Chemistry Letters, vol. 14, pp. 5269-5273, (2004).
Bebernitz et al., “Anilides of R-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase”, Journal of Medicinal Chemistry, vol. 43, pp. 7121-7124, (2000).
Bedsted et al., “Heparin and Calcium Ions Dramatically Enhance Antihrombin Reactivity With Factor IXa by Generating New Interaction Exosites” Biochemistry, vol. 42, pp. 8143-8152, (2003).
Benincosa et al., “Pharmacokinetics and Pharmacodynamics of a Humanized Monoclonal Antibody to Factor IX in Cynomolgus Monkeys” The Journal of Pharmacology and Experimental Therapeutics, vol. 292, pp. 810-816, (2000).
Blostein et al., “The Gla Domain of Factor IXa Binds to Factor VIIIa in the Tenase Complex” The Journal of Biological Chemistry, vol. 278, pp. 31297-31302, (2003).
Boitano et al., “Structure Activity Studies of a Novel Cytotoxic Benzodiazepine” Bioorganic & Medicinal Chemistry Letters, vol. 13, pp. 3327-3330, (2003).
Burdick et al, “N-Benzoyl Amino Acids as LFA-1/ICAM Inhibitors 1: Amino Acid Structure-Activity Relationship” Bioorganic Medicinal Chemistry Letters, vol. 13, pp. 1015-1018 (2003).
Burger et al., “Ein Neuer Allgemeiner Zugang Zu α-Trifluormethyl-Substituierten Aromatischen und Heteroaromatischen α-Aminosäuren” Synthesis, vol. 11, pp. 850-855, (1989).
Burk et al., 

Affiliated with

Also associated with

Rating

Aryl and heteroaryl compounds, compositions, and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aryl and heteroaryl compounds, compositions, and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aryl and heteroaryl compounds, compositions, and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3745054