Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-04-20
2000-12-26
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
51425406, 544362, 544366, 544370, 544238, 544295, 544357, 544360, 544363, 544367, 544369, 544373, 544379, 544392, 544394, 544395, A61K 31496, C07D40312, C07D48704
Patent
active
061660205
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.4, R.sup.23, R.sup.24, R.sup.25 and R.sup.26 are defined as in the specification.
These compounds are useful psychotherapeutics and are potent serotonin (5-HT.sub.1) agonists and antagonists.
REFERENCES:
patent: 5143916 (1992-09-01), Lavielle et al.
Millan et al, Journal of Pharmacology and Experimental Therapeutics, 262, pp. 451-463, 1992.
Chavloff et al, Journal of Pharmacology and Experimental Therapeutics, 243, pp. 1159-1166, 1987.
G Lennon et al, Drug Dev. Res 22 pp. 25-36, 1991.
S Axena, Pharmac. Ther. vol. 66, pp. 339-368, 1995.
Rasmussen et al, in Annual Reports in Medicinal Chemistry, pp. 1-9 (1995).
Chenard Bertrand L.
Desai Kishor A.
Howard, Jr. Harry R.
Macor John E.
Shenk Kevin D.
Bernhardt Emily
Ginsburg Dr. Paul H.
Nissenbaum Israel
Pfizer Inc.
Richardson Dr. Peter C.
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