Aryl/alkyl vinyl sulfone hyaluronic acid derivatives

Details Aryl/alkyl vinyl sulfone hyaluronic acid derivatives Aryl/alkyl vinyl sulfone hyaluronic acid derivatives

2007-03-02

2011-12-06

Olson, Eric S (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C514S054000

Reexamination Certificate

active

08071757

ABSTRACT:
A hyaluronic acid derivative, and methods of producing and using said derivative, the derivative comprising n repeating units and having the general structural formula (I), wherein, in at least one repeating unit, one or more of R1, R2, R3, R4 comprises an etherbound aryl/alkyl sulfone having the general structural formula (II), wherein R comprises an alkyl- or aryl-group, and otherwise R1, R2, R3, R4 are hydroxyl groups, OH.

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Hahn et al., “Anti-inflammatory drug delivery from hyaluronic acid hydrogels” J. Biomater. Sci. Polymer Edn, (2004) vol. 15 No. 9, pp. 1111-1119.
Laurent et al. The Faseb Journal, vol. 6, pp. 2397-2404 (1992).
Toole, Cell Biology of the Extracellular Matrix, pp. 305-341 (1991).

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