Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppress

Details Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppress Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppress

1994-06-15

1999-03-09

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D26722, C07D28118, C07D33716, C07D51300

Patent

active

058802800

ABSTRACT:
Aryl, alkyl, alkenyl and alkynyl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by modification at C-30, C-33, and/or C-34 of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.

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Organ, et al., Abstract & Program Book--24th Nat'l Med. Chem. Symp., p. 99 (Jun. 21-25, 1994), "Novel Derivatives Based Upon Modifications of the Cyclohexyl Ring of L-683,590 . . . ".

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